Thermo Fisher Scientific JAM-A (CD321) Monoclonal Antibody (H202-106), Biotin

Applications

• Flow Cytometry (Flow): Neat-1:5
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Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Rat anti-Mouse CD321 antibody, clone H202-106 recognizes murine CD321, also known as junctional adhesion molecule 1 (JAM-1).
CD321 is a 274 amino acid, approximately 32–41 kDa single-pass, type I transmembrane glycoprotein, which shares similarities with JAM-2 and JAM-3.

Target Information

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors.
It is a 32–41 kDa glycoprotein with two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail.
The protein assembles as a homodimer and can associate with other membrane proteins such as integrins.
CD321 is expressed on leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and mediates cell-cell contact.
It is closely associated with epithelial tight junction components such as ZO-1 and occludin, and plays roles in maintaining epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.