Thermo Fisher Scientific CEA Monoclonal Antibody (ABM330)
Human CEA(CD66e) 단백질을 인식하는 Mouse IgG1 단일클론 항체. WB, IHC, ELISA 등 다양한 응용에 사용 가능. Protein A로 정제된 액상 형태로 제공되며, 안정화 PBS buffer에 0.01% sodium azide 포함. 연구용 전용.
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Thermo Fisher Scientific CEA Monoclonal Antibody (ABM330)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM330 |
| Immunogen | Full length human CEA recombinant protein (Target family: CD66e (CEACAM5), UniProt ID: P06731-1, Antigen range: 1–702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human kidney clear cell carcinoma
- Cellular location: Cell membrane
Target Information
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during fetal development in the gut and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, consisting of one N domain and six constant-like A and B domains.
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell adhesion molecule found on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic binding. It plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants exist, though not all are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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