Thermo Fisher Scientific RNA pol II CTD Polyclonal Antibody
RNA pol II CTD를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Human, Mouse, Rat에 반응하며 WB, IHC, ICC/IF에 사용 가능. 1 mg/mL 농도의 액상 형태로, PBS와 50% glycerol에 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific RNA pol II CTD Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POLA1 (Accession P09884), corresponding to amino acid residues G91–C141 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899765 |
Product Specific Information
Antibody detects endogenous levels of total DNA Polymerase alpha.
Target Information
RNA polymerase II is the enzyme responsible for the synthesis of mRNA and many non-coding RNAs.
POLR2A encodes RNA polymerase II subunit B1 (RPB1), the largest subunit of RNA polymerase II.
The C-terminal domain (CTD) of RPB1 contains tandem heptapeptide repeats with the consensus sequence YSPTSPS.
Phosphorylation and other modifications within this sequence influence the recruitment of factors that regulate the transcription cycle.
Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the CTD.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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