Thermo Fisher Scientific Dicer Polyclonal Antibody
Dicer 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 항체로, PBS+50% glycerol에 보관. 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DICER1 (Accession Q9UPY3), corresponding to amino acid residues K1516–L1566 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899760 |
Product Specific Information
Antibody detects endogenous levels of total Dicer.
Target Information
Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of 21–23 nucleotides with a 3′ overhang of two nucleotides, producing short interfering RNAs (siRNA) and mature microRNAs. These siRNAs and miRNAs guide the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or inhibit their translation.
RNA interference via siRNAs regulates the elimination of transcripts from mobile and repetitive DNA elements and degradation of exogenous viral RNA, while the miRNA pathway specifically regulates gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-115124_Dicer_Q9UPY3-1_Rabbit.svg, PA5-115124_Dicer_Q9UPY3-1_Rabbit_PDP.jpeg)
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