Thermo Fisher Scientific HSD3B2 Polyclonal Antibody

Thermo Fisher Scientific HSD3B2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen, and the purity is >95% (by SDS-PAGE).

Target Information

3 beta-hydroxysteroid dehydrogenase (3β-HSD), also known as HSD3B1 or HSD3B2, is a bifunctional enzyme crucial for the synthesis of all classes of hormonal steroids. Two human 3β-HSD proteins, designated type I (3β-HSD1) and type II (3β-HSD2), are expressed by different genes and function in different tissues.
Localized to the membrane of the endoplasmic reticulum (ER) and expressed in skin and placenta, 3β-HSD type I catalyzes the oxidative conversion of delta5-ene-3β-hydroxy steroids and various ketosteroids.
Defects in the gene encoding 3β-HSD are associated with classic salt wasting, genital ambiguity, hypogonadism, insulin-resistant polycystic ovary syndrome (PCOS), and increased susceptibility to prostate cancer.
Congenital deficiency of 3β-HSD activity can result in severe depletion of steroid formation, which may be lethal in young children.

Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.