Thermo Fisher Scientific ETS1 (Marker of Tumor Metastasis) Monoclonal Antibody (ETS1/1801)
ETS1 종양 전이 마커를 인식하는 Mouse Monoclonal Antibody로, ELISA 및 Peptide Array에 사용 가능. Human 시료에 반응하며 Protein A/G로 정제된 액상 형태. 4°C 보관, 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ETS1/1801 |
| Immunogen | Recombinant human ETS1 fragment (around aa137–230) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family. It is a multifunctional transcription factor composed of an N-terminal pointed domain, a central transactivation domain, and two auto-inhibitory domains flanking the conserved C-terminal ETS domain. ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, mediating transactivation of genes including Osteopontin, Presenilin-1, Stromelysin, and Collagenase. Activated by Ras/MAPK signaling, its expression is upregulated in resting T-cells. ETS1 activity is modulated by AP-1, Sp-1, c-Myb, and MafB, and it interacts with Sp100, EAP1/Daxx, STAT6, and GATA3, influencing gene expression and transcriptional regulation in various signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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