Thermo Fisher Scientific ETS1 (Marker of Tumor Metastasis) Monoclonal Antibody (ETS1/1801)
ETS1 종양 전이 마커 단일클론 항체로 인간 ETS1 단백질을 특이적으로 인식합니다. ELISA 및 Peptide Array에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 2–4 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ETS1/1801 |
| Immunogen | Recombinant human ETS1 fragment (around aa137–230) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein belonging to the DNA-binding ETS family.
It is a multifunctional protein with:
- N-terminal pointed domain
- Central transactivation domain
- Two auto inhibitory domains flanked by conserved C-terminal ETS domain
ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, mediating transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
It is activated by Ras/MAPK signaling and up-regulated in resting T-cells.
ETS1 activity is modulated by AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies.
It interacts with EAP1/Daxx to repress MMP1 and BCL2 transactivation, and with STAT6 to modulate Socs-1 expression induced by IL-4.
ETS1 also interacts with GATA3 to positively regulate Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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