Thermo Fisher Scientific LARP1 Polyclonal Antibody
LARP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 인간에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반 보존액에 포함되어 있으며 연구용으로 적합.
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Thermo Fisher Scientific LARP1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 661–1019 of LARP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2553222 |
Product Specific Information
- Recommended positive controls: IMR32, SK-N-AS
- Predicted reactivity: Mouse (98%), Xenopus laevis (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in response to growth signals and nutrient availability.
Interacts with both the 3′ poly-A tails and the 7-methylguanosine cap structure of mRNAs containing a 5′TOP motif.
This interaction represses translation by preventing EIF4G1 binding; phosphorylation by mTORC1 releases this repression.
LARP1 associates with ribosomes and stabilizes mRNAs with a 5′TOP motif, promoting protein synthesis and cell growth.
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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