Thermo Fisher Scientific NAGA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, less than 2% cross-reactivity with recombinant human alpha-galactosidase A is observed.
• Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 amino acid lysosomal protein belonging to the glycosyl hydrolase 27 family. It functions as a homodimer and plays a key role in glycolipid breakdown.
The NAGA gene encodes alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Located on human chromosome 22q13.2, mutations in NAGA cause Schindler disease (types I, II, and III), a lysosomal storage disorder with varying neurological severity. Type I is the most severe, while type III presents milder symptoms. Type II (Kanzaki disease) is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.