Thermo Fisher Scientific NAGA Polyclonal Antibody
Thermo Fisher Scientific의 NAGA Polyclonal Antibody는 인간 NAGA 단백질을 인식하는 sheep 유래 다클론 항체입니다. Western blot과 ICC/IF에 최적화되어 있으며, 높은 특이성과 낮은 교차반응성을 보입니다. 동결건조 형태로 제공되며, 항원 친화 크로마토그래피로 정제되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human alpha-N-acetylgalactosaminidase (NAGA) Leu18–Gln411 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609331 |
Product Specific Information
- In direct ELISAs, less than 2% cross-reactivity with recombinant human alpha-galactosidase A is observed.
- Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 amino acid lysosomal protein belonging to the glycosyl hydrolase 27 family. It functions as a homodimer and plays a key role in glycolipid breakdown.
The NAGA gene encodes alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Located on human chromosome 22q13.2, mutations in NAGA cause Schindler disease (types I, II, and III), a lysosomal storage disorder with varying neurological severity. Type I is the most severe, while type III presents milder symptoms. Type II (Kanzaki disease) is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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