Thermo Fisher Scientific MCAM (Melanoma Cell Adhesion Molecule)/MUC18/CD146 Monoclonal Antibody (MCAM/3179)
인간 MCAM/CD146 단백질을 인식하는 Mouse monoclonal antibody. ELISA 및 Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 저장. 세포 접착 및 신호전달 관련 연구에 적합.
- 카탈로그번호
- 4162-MSM9-P1ABX
- 판매단위
- pk
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Applications
ELISA
- Tested Dilution: 2–4 µg/mL
Peptide Array
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MCAM/3179 |
| Immunogen | Recombinant human MCAM protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and various normal and malignant cell types.
CD146 functions as a calcium-independent cell adhesion molecule and a signal transduction molecule, recruiting Fyn kinase and inducing tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly.
It plays a key role in endothelial cohesion and melanoma cell interaction with vascular elements, facilitating tumor spread. Additionally, CD146 may act as an adhesion molecule in neural crest cells during embryonic development and as a surface receptor triggering phosphorylation of FYN and PTK2, leading to transient increases in intracellular calcium concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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