Thermo Fisher Scientific Phospho-MCM2 (Ser53) Polyclonal Antibody
MCM2 단백질의 Ser53 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. PBS/glycerol buffer에 보관되며 -20°C 저장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MCM2 (Accession P49736), corresponding to amino acid residues around phosphorylated Ser53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817585 |
Product Specific Information
This antibody detects endogenous levels of MCM2 only when phosphorylated at Ser53.
Target Information
MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. Also known as CDCL1, mitotin, and BM28, MCM2 is a human nuclear protein crucial for the cell cycle, especially in the onset of DNA replication and cell division. It is related to early S-phase proteins and mapped to chromosome 3q21. CDCL1 is a candidate oncogene affected by chromosomal breaks in acute myeloid leukemia (AML).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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