Thermo Fisher Scientific beta B1 Crystallin Polyclonal Antibody

Applications 및 Tested Dilution

Product Specifications

Target Information

Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of vertebrate eye lens and maintains its transparency and refractive index. Lens central fiber cells lose their nuclei during development, so crystallins are synthesized and retained throughout life, making them extremely stable proteins.

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins form a superfamily. Alpha and beta families are further divided into acidic and basic groups. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, absent in the acidic group). Beta-crystallins form aggregates of different sizes and can self-associate to form dimers or heterodimers with other beta-crystallins. The beta B1 gene undergoes extensive cleavage at its N-terminal extension during lens maturation and is part of a gene cluster with beta-A4, beta-B2, and beta-B3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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