Thermo Fisher Scientific CD146 Polyclonal Antibody
Rabbit polyclonal antibody against human CD146 (MCAM) for WB and IP applications. Recognizes residues 596–646 of CD146. Supplied as liquid, 1 mg/mL, unconjugated. Store at 4 °C. Predicted cross-reactivity with rat.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 596–646 of human Melanoma Adhesion Molecule (CD146) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4 °C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell–cell junctions in endothelial cells and in various normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and may act as a signal transduction molecule through recruitment of Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. It plays a role in endothelial cohesion, vascular integrity, and melanoma cell interaction with vascular elements, possibly enhancing tumor spread. CD146 may also function during neural crest cell development and act as a surface receptor triggering phosphorylation of FYN and PTK2 and transient increases in intracellular calcium concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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