Thermo Fisher Scientific IL1F9 Monoclonal Antibody (OTI2F4)
IL1F9 단백질을 인식하는 마우스 단클론 항체로, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 시료에 반응하며, 고순도 친화 크로마토그래피 정제. 안정적인 액상 형태로 장기 보관 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F4 |
| Immunogen | Full length human recombinant protein of IL1F9 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724517 |
Target Information
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system, which is involved in local inflammatory responses in epithelial barriers. Plays a role in skin inflammation by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation, and proliferation.
In cultured keratinocytes, it induces expression of macrophage, T-cell, and neutrophil chemokines such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20, and CXCL1. It also stimulates its own expression and that of TNF-alpha, S100A7/psoriasin, and inducible NOS. May contribute to proinflammatory responses in neutrophilic airway inflammation by activating MAPKs and NF-kappa B in primary lung fibroblasts, and stimulating IL-8, CXCL3, and Th17 chemokine CCL20 expression. Also involved in innate immune response to fungal pathogens like Aspergillus fumigatus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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