Thermo Fisher Scientific IL1F9 Monoclonal Antibody (OTI2F4)

Applications

Product Specifications

Target Information

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system, which is involved in local inflammatory responses in epithelial barriers. Plays a role in skin inflammation by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation, and proliferation.

In cultured keratinocytes, it induces expression of macrophage, T-cell, and neutrophil chemokines such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20, and CXCL1. It also stimulates its own expression and that of TNF-alpha, S100A7/psoriasin, and inducible NOS. May contribute to proinflammatory responses in neutrophilic airway inflammation by activating MAPKs and NF-kappa B in primary lung fibroblasts, and stimulating IL-8, CXCL3, and Th17 chemokine CCL20 expression. Also involved in innate immune response to fungal pathogens like Aspergillus fumigatus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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