Thermo Fisher Scientific CXCR5 Recombinant Rabbit Monoclonal Antibody (JB11-40)
CXCR5 단백질을 인식하는 토끼 단클론 항체로, WB, IHC, Flow Cytometry 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, HEK293 세포에서 발현된 재조합 항체입니다. 단백질 A로 정제되어 높은 순도와 재현성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2000–1:5000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB11-40 |
| Immunogen | Synthetic peptide within C-terminal human CXCR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2899011 |
Target Information
CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family.
It is a G protein-coupled seven-transmembrane receptor for chemokine BLC and is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.
CXCR5 plays an essential role in B cell migration and is expressed in various human and animal tissues including blood, salivary gland, lymph nodes, spleen, and brain.
G-protein Coupled Receptors (GPCRs) constitute one of the largest families of signaling molecules, characterized by seven membrane-spanning helices.
They exist in active and inactive forms and interact with diverse ligands to mediate cellular signaling via G-proteins and downstream effectors.
GPCR regulation mechanisms have significant implications in physiology and pharmacology, leading to the development of major drugs such as Zyprexa and Claritin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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