Thermo Fisher Scientific Factor XIII A Recombinant Rabbit Monoclonal Antibody (PD00-08)
Factor XIII A 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD00-08 |
| Immunogen | Synthetic peptide within Human Factor XIIIa C terminal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931120 |
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin. Upon activation by thrombin and calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme, factor XIIIa. This enzyme acts as a transglutaminase, catalyzing crosslinking between fibrin molecules to stabilize the clot, and also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin. Factor XIII deficiency can lead to bleeding tendency, poor wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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