Thermo Fisher Scientific CD103 Monoclonal Antibody (2E7), FITC
CD103 단백질을 표적하는 FITC 결합 단일클론 항체로, Flow Cytometry 및 Immunoprecipitation에 사용 가능. 마우스 반응성, Armenian hamster 유래 IgG2 아이소타입. 고순도 액상 형태로 제공되며, PBS 버퍼에 0.1% sodium azide 포함. 4°C 암소 보관.
- 카탈로그번호
- HMCD10301
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- pk
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Thermo Fisher Scientific CD103 Monoclonal Antibody (2E7), FITC
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.1–0.2 µg / 1×10⁶ cells | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Armenian hamster / IgG2 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E7 |
| Immunogen | Mouse CD103 from C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536591 |
Alternative Formats
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes and activated cells, particularly on subsets of TGF-β1–responsive cells. It includes a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs, staining a few bone marrow cells and rarely peripheral blood lymphocytes.
It belongs to the integrin family, composed of heterodimeric integral membrane proteins (alpha and beta chains). The ITGAE gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage, forming disulfide-linked heavy and light chains. Together with beta 7 integrin, CD103 forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen.
CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL) and may act as an accessory molecule for IEL activation.
Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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