Thermo Fisher Scientific CTLA-4 Monoclonal Antibody (1B8), FITC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.1-0.2 µg / 1x10^6 cells

View 3 publications 3 publications

ELISA (ELISA)

3 µg/10^6 cells

-

Neutralization (Neu)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Armenian hamster / IgG1

Class

Monoclonal

Type

Antibody

Clone

1B8

Immunogen

Mouse CD152 (CTLA-4). from Extracellular portion of murine CTLA-4 fused to a murine IgG2a

Conjugate

FITC FITC FITC

View additional formats

• PE
• Request custom conjugation

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

purified

Storage buffer

PBS, pH 7.4

Contains

<0.1% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice (domestic); Wet or Dry ice (international)

RRID

AB_2536593

Target Information

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.