Gibco™

Human Plateable Hepatocytes, Metabolism Qualified

These cryopreserved human hepatocytes are suitable for use in plated metabolism applications. Cells per vial: 4-8 million Prototypical cytochrome P450자세히 알아보기

These cryopreserved human hepatocytes are suitable for use in plated metabolism applications.

Cells per vial: 4-8 million

Prototypical cytochrome P450 substrates midazolam, tolbutamide, and dextromethorphan were used to assess the enzymatic function of CYP3A4⁄5, CYP2C9 and CYP2D6 respectively. The disappearance of parent was monitored by LC-MS⁄MS analysis and intrinsic clearance (CLint) values determined by linear regression.

Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, proper cell morphology, and metabolic activity increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound`s fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.

Each lot is tested for:
• Viability ≥ 70%
• Attachment efficiency
• Monolayer formation and integrity
• Confluency >70% on Day 2
• Tested for plating in 96 well format
• Phase I enzyme activities
• Relevant CYP450 polymorphisms

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Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.

사양

셀 유형Hepatocytes

Culture TypeMammalian Cell Culture

형태Cryopreserved

종Human

공여자 소스Single Donor

셀 수4-8 x 106

제품라인Gibco™

제품 유형Hepatocytes

수량1.5 mL

Unit SizeEach