Thermo Fisher Scientific AKR1C3 Polyclonal Antibody
AKR1C3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AKR1C3 (Accession P42330), corresponding to amino acid residues E291–Y323 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854555 |
Product Specific Information
Antibody detects endogenous levels of total AKR1C3.
Target Information
AKR1C3 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. AKR1C3 catalyzes the reduction of prostaglandin D2, PGH2, and phenanthrenequinone, and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play a role in allergic disease pathogenesis such as asthma and in regulating cell growth or differentiation. The gene shares high sequence identity with three other family members and is located at chromosome 10p15–p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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