Thermo Fisher Scientific MPZ Polyclonal Antibody
MPZ 단백질을 검출하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MPZ (Accession P25189), corresponding to amino acid residues K204–K248 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854551 |
Product Specific Information
Antibody detects endogenous levels of total MPZ.
Target Information
Myelin Protein Zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath, ensuring stable synaptic transmission. MPZ constitutes approximately 50% of total protein in the sheath scaffolding, contributing to structural integrity of peripheral myelin. It guides compact myelin wrapping through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations such as G134R can disrupt multimer formation, leading to demyelinating neuropathies including Charcot-Marie-Tooth disease. The cytoplasmic domain undergoes serine and tyrosine phosphorylation, prevalent during peak nerve myelination. MPZ transcript is moderate in brain, abundant in thymus, and most abundant in white matter of the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-106887_MPZ_P25189-1_Rabbit.svg, PA5-106887_MPZ_P25189-1_Rabbit_PDP.jpeg)
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