Thermo Fisher Scientific EDG6 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is RH7777 cells transfected with EDG6 protein lysate.

Target Information

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family, which mediate growth-related effects such as induction of cellular proliferation, differentiation, survival, and suppression of apoptosis.
They also regulate cytoskeletal-dependent cellular functions including contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and exhibit tissue-specific expression. They couple to multiple G proteins to signal through Ras, MAP kinase, Rho, phospholipase C, and several tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissues and in the lungs. The updated nomenclature for EDG6 (S1P4) is sphingosine 1-phosphate receptor-4 (S1P4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.