Thermo Fisher Scientific Phospho-c-Abl (Tyr245) Monoclonal Antibody (S.44.4)
Phospho-c-Abl (Tyr245) 단클론 항체로 인간 및 마우스 시료에 반응. Western blot에 적합하며, 비활성 단백질 티로신 키나아제와 교차 반응 없음. 액상 형태로 친화 크로마토그래피 정제. -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.44.4 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr245 of human c-Abl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10987012 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other activated protein tyrosine kinases.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
c-Abl activity is negatively regulated by its SH3 domain, and deletion of this domain transforms it into an oncogene.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) chromosomal translocation creates the Philadelphia chromosome, fusing c-Abl from chromosome 9 with the Bcr gene on chromosome 22.
c-Abl may also regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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