Thermo Fisher Scientific Factor 8a light chain Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300

ELISA

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation. Factor VIII acts as a cofactor for factor IXa, which, in the presence of Ca²⁺ and phospholipids, converts factor X to the activated form Xa.
Two alternatively spliced transcripts are produced:

• Transcript variant 1 encodes isoform a, a large glycoprotein circulating in plasma, associated with von Willebrand factor.
• Transcript variant 2 encodes isoform b, a smaller protein mainly consisting of the phospholipid-binding domain essential for coagulant activity.

Defects in this gene result in hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.