Thermo Fisher Scientific GPNMB Polyclonal Antibody
Thermo Fisher Scientific의 GPNMB Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Western blot과 ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, recombinant GPNMB(aa 23–486)를 면역원으로 사용했습니다. 액상 형태로 2.25 mg/mL 농도이며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
- Publications: View 1 publication
ELISA
- Tested Dilution: 1 µg/mL
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 23–486 of human GPNMB (NP_001005340.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805741 |
Product Specific Information
- Positive Samples: A-549, K-562, U-87MG, Mouse brain, Mouse liver, Rat brain, Rat liver
- Cellular Location: Cell membrane, Melanosome, Single-pass type I membrane protein
Immunogen Sequence:
KRFHDVLGNE RPSAYMREHN QLNGWSSDEN DWNEKLYPVW KRGDMRWKNS WKGGRVQAVL TSDSPALVGS NITFAVNLIF PRCQKEDANG NIVYEKNCRN EAGLSADPYV YNWTAWSEDS DGENGTGQSH HNVFPDGKPF PHHPGWRRWN FIYVFHTLGQ YFQKLGRCSV RVSVNTANVT LGPQLMEVTV YRRHGRAYVP IAQVKDVYVV TDQIPVFVTM FQKNDRNSSD ETFLKDLPIM FDVLIHDPSH FLNYSTINYK WSFGDNTGLF VSTNHTVNHT YVLNGTFSLN LTVKAAAPGP CPPPPPPPRP SKPTPSLATT LKSYDSNTPG PAGDNPLELS RIPDENCQIN RYGHFQATIT IVEGILEVNI IQMTDVLMPV PWPESSLIDF VVTCQGSIPT EVCTIISDPT CEITQNTVCS PVDVDEMCLL TVRRTFNGSG TYCVNLTLGD DTSLALTSTL ISVP
Target Information
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein.
GPNMB shows expression in lowly metastatic human melanoma cell lines and xenografts but not in highly metastatic cell lines.
It may be involved in growth delay and reduction of metastatic potential.
Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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