Thermo Fisher Scientific ADAM10/KUZ Polyclonal Antibody
ADAM10/KUZ 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. Human과 Mouse 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of ADAM10 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Reh leukemia cells
- Cellular location: Membrane
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to various inflammatory responses and programmed cell death. The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma. TNF-a, Notch, and its ligand Delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors. ADAM10, a metalloprotease-disintegrin in the mammalian ADAM family (a disintegrin and metalloprotease), was identified to cleave TNF-a, Notch, and Delta. The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, Kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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