Thermo Fisher Scientific TRPM6 Polyclonal Antibody
Zebrafish TRPM6 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 합성 펩타이드 면역원으로 제작되어 높은 특이성 제공. 동결건조 형태로 제공되며 4°C 또는 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1450–1500 of zebrafish TRPM6 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM6.
Target Information
TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing both an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, playing an essential role in epithelial magnesium transport and active magnesium absorption in the gut and kidney.
Mutations in TRPM6 are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been observed.
TRPC7 is thought to form a receptor-activated, non-selective calcium-permeant cation channel, likely operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors, and also activated by diacylglycerol (DAG) or intracellular calcium store depletion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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