Thermo Fisher Scientific ATXN1L Polyclonal Antibody
Rabbit polyclonal antibody against human ATXN1L protein for ICC/IF applications. Recombinant immunogen-based with high species conservation. Supplied as liquid, unconjugated, purified by antigen affinity chromatography. Ideal for chromatin-binding and ...
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATXN1L. Recombinant protein control fragment (Product #RP-107195) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662503 |
Product Specific Information
Immunogen sequence:
HPGIHYPPLHY AQLPSTSLQF IGSPYSLPYA VPPNFLPSPL LSPSANLATS HLPHFVPYAS LLAEGATPP
- Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 93%
Target Information
Chromatin-binding factor that represses Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor.
Binds to the HEY promoter and may assist, along with NCOR2, in RBPJ-mediated repression (PubMed:21475249).
Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1).
In concert with CIC and ATXN1, involved in brain development. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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