Thermo Fisher Scientific ZN692 Polyclonal Antibody
ZNF692 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 ICC/IF에 적합합니다. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. PBS(40% glycerol) 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- PA566533
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ZN692. Recombinant protein control fragment (Product #RP-105243) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664613 |
Product Specific Information
Immunogen sequence:
ASTGSQAQSAP TPAWDEDTAQ IGPKRIRKAA KRELMPCDFP GCGRIFSNRQ YLNHHKKYQH IHQKSFSCP
Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 89%
Target Information
ZNF692, a zinc finger protein, is involved in several cellular processes including nucleolar organization and ribosome biogenesis. It interacts with nucleophosmin (NPM1), regulating nucleolar morphology by modifying NPM1’s self-assembly properties and influencing protein synthesis. Knockdown of ZNF692 causes nucleolar redistribution of NPM1 and results in a decreased rate of protein synthesis. Additionally, ZNF692 plays a role in 40S ribosomal subunit maturation by forming a hub with the exosome complex and ribosome biogenesis factors. This gene is upregulated in certain cancers such as clear cell renal cell carcinoma (ccRCC), where its expression is associated with increased cell proliferation, migration, and poor overall survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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