Thermo Fisher Scientific Human Artemin, Animal-Free Recombinant Protein, PeproTech

Applications

• Functional Assay (Functional)

Tested Dilution: Assay-dependent
Publications: References

Product Specifications

Product Specific Information

The functional human Artemin ligand is a disulfide-linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine-knot configuration.
Recombinant Human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits.

This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please see the lot-specific Certificate of Analysis.

Target Information

The protein encoded by this gene is a member of the glial cell line-derived neurotrophic factor (GDNF) family of ligands, which belong to the TGF-beta superfamily of signaling molecules. GDNFs have unique neurotrophic properties and potential use in gene therapy for neurodegenerative diseases.
Artemin supports the survival of various peripheral neuron populations and dopaminergic CNS neurons. Its role in the PNS and CNS is substantiated by its expression near these neurons. This protein acts as a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.