Thermo Fisher Scientific GABA Transporter 3 (GAT-3) Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The Slc6a11 gene encodes GABA transporters that are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6). These transporters mediate rapid removal of GABA and maintain low extracellular levels.
Four 12-transmembrane domain transporters have been identified and localized to neurons and glia.
The protein encoded by Slc6a11 is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, terminating GABA neurotransmission.
Defects in Slc6a11 may result in epilepsy, behavioral, or intellectual problems.
Two transcript variants encoding different isoforms have been found for Slc6a11.
Diseases associated with SLC6A11 include Tricuspid Valve Stenosis and Pulmonary Valve Insufficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.