Thermo Fisher Scientific CDC20 Polyclonal Antibody
CDC20 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 4°C 보관 및 습식 얼음 배송. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human cell division cycle 20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Pig
Target Information
CDC20 is required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex.
It is regulated by MAD2L1: in metaphase, the MAD2L1–CDC20–APC/C ternary complex is inactive, and in anaphase, the CDC20–APC/C binary complex is active in degrading substrates.
The CDC20–APC/C complex positively regulates synaptic vesicle clustering at the presynaptic membrane in postmitotic neurons.
CDC20–APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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