Thermo Fisher Scientific c-Myc Recombinant Rabbit Monoclonal Antibody (2O3U10)
c-Myc 단백질 검출용 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot, ELISA, ChIP, CUT&RUN 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, 핵 및 핵소체 내 c-Myc 단백질 검출에 유용합니다.
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Thermo Fisher Scientific c-Myc Recombinant Rabbit Monoclonal Antibody (2O3U10)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
| ChIP assay (ChIP) | 5 µg antibody for 10–15 µg of chromatin |
| CUT&RUN (C&R) | 10⁵ cells / 1 µg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2O3U10 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human c-Myc (P01106) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.11 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911816 |
Product Specific Information
- Positive test controls: Jurkat, MCF7, Mouse ovary
- Localization: Nucleus, nucleolus, nucleoplasm
- Immunogen sequence:
MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates c-Myc function. Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis in tumor development.
The c-Myc oncogene is involved in normal cellular proliferation and differentiation, while deregulated expression induces apoptosis.
Amplification of c-Myc has been reported in lung, breast, and colon carcinomas, and translocations involving the c-Myc locus are described in Burkitt’s lymphoma and other B-cell proliferative disorders.
Aberrant expression of c-Myc occurs in tumors of various origins including colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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