Thermo Fisher Scientific C5AR1 Monoclonal Antibody (8D6)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-dependent

Flow Cytometry (Flow)

• 1 µg/1 million cells

Product Specifications

Additional Formats

• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

MA1-70060 detects C5a receptor in human samples.
It has been successfully used in flow cytometry and immunohistochemistry (frozen sections).
The immunogen is RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.

Target Information

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production.
It is also a component of the classical pathway of the complement cascade and may be involved with tissue injury associated with ischemia or sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.