Thermo Fisher Scientific Insulin/IRDN (beta-Cell and Insulinoma Marker) Monoclonal Antibody (IRDN/805)

Thermo Fisher Scientific Insulin/IRDN (beta-Cell and Insulinoma Marker) Monoclonal Antibody (IRDN/805)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
• Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Does not react with Rat

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids.
Insulin is a 51-amino-acid polypeptide produced from the precursor peptide proinsulin, which is post-translationally cleaved into two chains (peptide A and peptide B) covalently linked via two disulfide bonds and one molecule of C-peptide.
Insulin deficiency results in diabetes mellitus, a major cause of morbidity and mortality. Insulin is also present in tumors of β-cell origin such as insulinoma.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.