Thermo Fisher Scientific Factor XII Heavy chain Monoclonal Antibody (B7C9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

-

ELISA (ELISA)

1-10 µg/mL

-

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

B7C9

Immunogen

Purified human Factor XII. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Factor XII Heavy chain,uniProtId:P00748-1,ncbiNodeId:9606,antigenRange:1-615,antigenLength:615,antigenImageFileName:MA1-10828_Factor_XII_Heavy_chain_P00748-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10828_Factor_XII_Heavy_chain_P00748-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1074352

Product Specific Information

MA1-10828 detects Factor XII heavy chain, from human samples.

MA1-10828 has been successfully used in ELISA and Western blot applications. By Western blot, this antibody detects a ~50 kDa band representing the non-reduced heavy chain of Factor XII from normal human plasma .

The MA1-10828 immunogen is purified human Factor XII.

Target Information

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.