Thermo Fisher Scientific Bcl-2 Polyclonal Antibody
Bcl-2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 항원은 인간 Bcl-2 N-말단 15개 아미노산 서열 기반으로 제작되었으며, 액상 형태로 1 mg/mL 농도 제공.
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Thermo Fisher Scientific Bcl-2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 4 publications |
| Immunohistochemistry (IHC) | – | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | – |
| ELISA | – | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 15 amino acids near the N terminus of human Bcl-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; for long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152761 |
Product Specific Information
- Suggested positive control: Daudi cell lysate
- Can be used with blocking peptide PEP-0187
- Immunogen located within the first 50 amino acids of Bcl-2
- Predicted molecular weight: ~26 kDa
- Observed Western blot band: 26 kDa
- Predicted species reactivity based on immunogen sequence:
- Bovine (100%)
- Rat (100%)
- Chicken (93%)
Target Information
BCL-2 is a key regulator of apoptosis that can inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis. Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak play critical roles in cytochrome c release from mitochondria, initiating apoptosis. Constitutive expression of BCL-2, such as through translocation to the Ig heavy chain locus, is associated with follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, while normal centers are negative. Two transcript variants of BCL-2 differ in their C-terminal ends. Overexpression of BCL-2 has been linked to cancers including B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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