Thermo Fisher Scientific IL-8 (CXCL8) Polyclonal Antibody
Human IL-8(CXCL8)에 특이적인 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 보존됩니다. 염증 반응 및 케모카인 연구용으로 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of Human IL-8 (amino acids 1–99) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802829 |
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, which bind to the cell surface receptors IL-8RA and IL-8RB. IL-8 acts as a chemoattractant and potent angiogenic factor. Its expression and secretion can be induced by various inflammatory stimuli in multiple cell types, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
IL-8, first isolated from osteosarcoma cells, contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C. The IL-8 gene, along with ten other CXC chemokine genes, forms a cluster mapped to chromosome 4q.
IL-8 is implicated in angiogenesis and tumor growth, and is believed to play a role in the pathogenesis of bronchiolitis, a common viral respiratory tract disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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