Thermo Fisher Scientific NPTX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human NPTX2. Recombinant protein control fragment (Product #RP-103055). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NPTX2,uniProtId:P47972-1,ncbiNodeId:9606,antigenRange:373-431,antigenLength:431,antigenImageFileName:PA5-111299_NPTX2_P47972-1_Rabbit.svg,antigenImageFileNamePDP:PA5-111299_NPTX2_P47972-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856709

Product Specific Information

Immunogen sequence: LSQFNIWDRV LRAQEIVNIA NCSTNMPGNI IPWVDNNVDV FGGASKWPVE TCEERLLDL

Target Information

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson`s disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.