Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
NFVASHIANI LNSEELDIQD LKKLVKEALK ESQLPTVMDF RKFSRNYQLY KSVSLPSLDP ASAKIEGNLI FDPNNYLPKE SMLKTTLTAF GFASADLIE

Target Information

Apolipoprotein B (apo B) in human plasma is a major protein of low-density lipoproteins (LDL) with a molecular mass of approximately 260–500 kDa.
Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.

Low-density lipoprotein (LDL) acts as the carrier protein for cholesterol in the blood. LDL binds to its receptor on capillary walls, mediating uptake and clearance of cholesterol.
Oxidatively modified LDL is found in atherosclerotic lesions and recognized by macrophages via scavenger receptor A and CD36.
Apolipoprotein B is mainly synthesized in the liver and is a key component of LDL, VLDL, and lipoprotein(a).
It serves as a ligand for the LDL receptor, and elevated levels are associated with premature atherosclerosis.

Normal plasma apolipoprotein B levels are around 800 mg/L.
Two main isoforms exist: apoB-48 and apoB-100, encoded by a single gene.
ApoB-48 is produced via RNA editing of the apoB-100 transcript, creating a stop codon at residue 2180.
Mutations in the Apolipoprotein B gene or its regulatory region can cause hypobetalipoproteinemia or hypercholesterolemia due to ligand-defective apoB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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