Thermo Fisher Scientific HERV Polyclonal Antibody
인간 HERVW 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot에 최적화됨. 합성 펩타이드(C-말단, 406-435aa)를 면역원으로 사용. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 동결건조 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human ERVW-1 (406–435aa, YYVNQSGIVTEKVKEIRDRIQRRAEELRNT) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746336 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
HERVs are a class of multiple sclerosis–associated retroviruses. This antibody reacts with a replication-competent Human Endogenous Retrovirus (HERVW) isolated from placenta.
The synthetic peptide sequence used as immunogen is derived from the viral envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have retained, lost, or modified their original function through evolution.
The HERVW endogenous envelope protein retains fusogenic properties and participates in trophoblast fusion during placental morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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