Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1A12), TrueMAB
Human ALK 단백질(aa1300-1620)을 항원으로 제작된 Mouse IgG2a 단클론 항체. Western blot에 1:2,000 희석으로 사용 가능. 동결건조 형태로 제공되며, PBS/tTrehalose buffer에 보관. 뇌 발달 및 종양 관련 ALK 연구용에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been linked to various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often create a fusion gene between ALK (chromosome 2) and nucleophosmin (NPM, chromosome 5), producing the NPM-ALK oncogenic fusion protein.
ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK and playing critical roles in neuronal development.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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