Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI2B6), TrueMAB

Applications

Product Specifications

Target Information

Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in immune system development and regulation. The protein encoded by this gene forms a complex with regulatory factor X-associated protein and regulatory factor-5, binding to the X box motif of certain MHC class II promoters to activate transcription. This complex interacts with the non-DNA-binding factor MHC class II transactivator, determining cell type specificity and inducibility of MHC class II expression. The protein contains ankyrin repeats for protein-protein interactions. Mutations in this gene are associated with bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one showing activation activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.