Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI3F5), TrueMAB
RFXANK 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC, Flow Cytometry 등에 사용 가능. Human 시료에 반응하며, 고순도 Affinity chromatography 정제. PBS, BSA, glycerol 기반 저장용액에 보관하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F5 |
| Immunogen | Full length human recombinant RFXANK protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in the development and control of the immune system.
The protein encoded by the RFXANK gene, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription.
This complex associates with the non-DNA-binding factor MHC class II transactivator, which determines cell type specificity and inducibility of MHC class II gene expression.
The RFXANK protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene are linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one isoform showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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