Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI2F12), TrueMAB
RFXANK 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. Human 시료에 반응하며, 고순도 Affinity chromatography로 정제된 액상 항체. 연구용으로 MHC class II 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F12 |
| Immunogen | Full length human recombinant protein of human RFXANK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in immune system development and regulation.
The RFXANK protein, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of MHC class II gene promoters to activate transcription.
This complex associates with the non-DNA-binding factor MHC class II transactivator (CIITA), which controls the cell type specificity and inducibility of MHC class II gene expression.
RFXANK contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene are linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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