Thermo Fisher Scientific ENG Monoclonal Antibody (4C11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.3 ng/mL

-

Immunoprecipitation (IP)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

4C11

Immunogen

ENG (AAH14271, 27 a.a. approximately 658 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD105 (Endoglin),uniProtId:P17813-1,ncbiNodeId:9606,antigenRange:1-658,antigenLength:658,antigenImageFileName:H00002022-M01_CD105_Endoglin_P17813-1_House_mouse.svg,antigenImageFileNamePDP:H00002022-M01_CD105_Endoglin_P17813-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: TVHCDLQPVG PERDEVTYTT SQVSKGCVAQ APNAILEVHV LFLEFPTGPS QLELTLQASK QNGTWPREVL LVLSVNSSVF LHLQALGIPL HLAYNSSLVT FQEPPGVNTT ELPSFPKTQI LEWAAERGPI TSAAELNDPQ SILLRLGQAQ GSLSFCMLEA SQDMGRTLEW RPRTPALVRG CHLEGVAGHK EAHILRVLPG HSAGPRTVTV KVELSCAPGD LDAVLILQGP PYVSWLIDAN HNMQIWTTGE YSFKIFPEKN IRGFKLPDTP QGLLGEARML NASIVASFVE LPLASIVSLH ASSCGGRLQT SPAPIQTTPP KDTCSPELLM SLIQTKCADD AMTLVLKKEL VAHLKCTITG LTFWDPSCEA EDRGDKFVLR SAYSSCGMQV SASMISNEAV VNILSSSSPQ RKKVHCLNMD SLSFQLGLYL SPHFLQASNT IEPGQQSFVQ VRVSPSVSEF LLQLDSCHLD LGPEGGTVEL IQGRAAKGNC VSLLSPSPEG DPRFSFLLHF YTVPIPKTGT LSCTVALRPK TGSQDQEVHR TVFMRLNIIS PDLSGCTSKG LVLPAVLGIT FGAFLIGALL TAALWYIYSH TRSPSKREPV VAVAAPASSE SSSTNHSIGS TQSTPCSTSS MA

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.