Thermo Scientific™

GeneBLAzer™ OPRL1-Gqi5-NFAT-bla FreeStyle™ 293F Cells

The GeneBLAzer™ OPRL1-Gqi5-NFAT-bla FreeStyle™ 293F Cell Line contains the human opioid/opiate receptor-like-1 receptor (OPRL1) stably integrated into the GeneBLAzer™ Gqi5-NFAT-bla자세히 알아보기

The GeneBLAzer™ OPRL1-Gqi5-NFAT-bla FreeStyle™ 293F Cell Line contains the human opioid/opiate receptor-like-1 receptor (OPRL1) stably integrated into the GeneBLAzer™ Gqi5-NFAT-bla FreeStyle™ 293F Cell Line. GeneBLAzer™ Gqi5-NFAT-bla FreeStyle™ 293F cells (Cat. No. K1539) contain the chimeric Gqi5 G protein and the beta-lactamase reporter gene under control of the nuclear factor of activated T cells (NFAT) response element.

OPRL1-Gqi5-NFAT-bla FreeStyle™ 293F cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time, and functionally validated for Z-factor and EC50 concentrations of orphanin FQ/nociceptin. These data are found in the Validation & Assay Performance Summary.

Orphanin FQ/nociceptin and OPRL1 have been implicated in various physiological functions. The most defined role is their involvement in the mediation of pain in the central nervous system and their possible roles in opiate tolerance, opiate dependence and withdrawal, and the ability to cope with stress and anxiety. Through the use of antagonists, antisense oligos, and transgenic knockout mutants, OPRL1 has been implicated in additional systems including learning, memory, and reproduction.

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사양

등록 번호NM_000913

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

검출 방법Fluorescence

용도(애플리케이션)FRET

유전자 기호OPRL1

개체군 상태Single Cell Clone Origin

제품라인GeneBLAzer™

수량2 x 106 Cells

리포터 유전자BLA (Beta-Lactamase)

타겟 입력OPRL1

유형Cell Line

세포주FreeStyle 293-F Cells

System TypeGeneBLAzer™

Druggable TargetGPCR

Unit SizeEach