Thermo Fisher Scientific Syk Recombinant Rabbit Monoclonal Antibody (PSH0-76)
Thermo Fisher Scientific의 Syk Recombinant Rabbit Monoclonal Antibody (PSH0-76)은 인간 Syk 단백질을 인식하는 고특이성 항체로, WB 및 ICC/IF에 적합합니다. Expi293 시스템에서 발현된 재조합 단일클론 항체이며, Protein A로 정제된 1 mg/mL 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PSH0-76 |
| Immunogen | Synthetic peptide within human aa 451–500 / 635 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3075019 |
Product Specific Information
- Sequence Similarities: 100% Mouse
- Tissue Specificity: Widely expressed in hematopoietic cells (protein level). Expressed in neutrophils and across B-cell compartments (pro-, pre-B to plasma cells).
- Positive Control: Raji, Daudi, SW620, Ramos cell lysates
- Subcellular Location: Cell membrane, cytoplasm, cytosol
- Predicted Band Size: 72 kDa
Target Information
Spleen tyrosine kinase (SYK) is a cytoplasmic tyrosine kinase involved in immune signaling pathways. Together with ZAP70, SYK is a potential drug target for allergic and autoimmune disorders, and may play a role in cancer.
Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates adaptor proteins, initiating downstream signaling such as calcium mobilization, cytoskeleton remodeling, and transcriptional activation.
Syk interacts with receptor ITAM motifs via its SH2 domains, which are phosphorylated by Src-family kinases that also activate Syk through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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