Thermo Fisher Scientific IGF1R (extracellular) Polyclonal Antibody
IGF1R 단백질의 세포외 영역을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(F), Flow Cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, Lyophilized 형태로 제공됩니다. 인체, 마우스, 랫트 시료에 반응하며 연구용으로 사용됩니다.
- 카탈로그번호
- ANT-045-xxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IGF1R (extracellular) Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:120 |
| Flow Cytometry (Flow) | 2.5 µg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)RQEYRKYGGAKLNR, corresponding to amino acid residues 883–896 of rat IGF1R, Extracellular, N-terminus (beta chain) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships lyophilized at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge antibody preparations before use (10,000 × g for 5 min).
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers.
The protein is a tetramer of two alpha and two beta subunits.
Alpha-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at residues 1134, 1135, and 1136.
Activated IGF1R phosphorylates substrate proteins, triggering sequential activation of RAS, RAF, and MAPK isoforms (ERK, p38, JNK), leading to gene transcription and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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