Thermo Fisher Scientific RTN1 Polyclonal Antibody

Thermo Fisher Scientific RTN1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 1:2,500–1:5,000
• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SITPPSSGTE PSAAESQGKG SISEDELITA IKEAKGLSYE TAENPRPVGQ LADRPEVKAR SGPPTIPSPL DHEASSAESG DSEIELVS

Target Information

Reticulon-1 (RTN1), formerly designated NSP (Neuroendocrine-Specific Protein), is specifically expressed in neural and neuroendocrine tissues. The NSP gene is located on human chromosome 14q21–q22 and encodes three overlapping proteins:

• Reticulon-1A (NSP-A): ~135 kDa, various isoforms depending on phosphorylation; reliable marker for neuroendocrine differentiation in lung cancer diagnosis.
• Reticulon-1B (NSP-B): 45 kDa phosphoprotein, found in lung cancer cell line NCI-H82.
• Reticulon-1C (NSP-C): 23 kDa non-phosphorylated protein, co-expressed with Reticulon-1A in SCLC cell lines.

These proteins are anchored to endoplasmic reticulum membranes via their common carboxy-terminal regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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